岩手大学 理工学部 化学・生命理工学科 化学コース 有機精密合成化学研究室 是永研究室
論文publications
2025
総説・解説・著書Atroposelective Suzuki-Miyaura Coupling Toward Axially Chiral Biaryls: Mechanistic Insight (CHAPTER 4)
Toshinobu Korenaga
Atropisomerism in Asymmetric Organic Synthesis: Challenges and Applications, Editor(s):Shinobu Takizawa, Mohamed Salem, pp 69-90, John Wiley & Sons, Inc, 2025.
2024
原著論文
Catalytic Concerted SNAr Reactions of Fluoroarenes by an Organic Superbase
Masanori Shigeno,* Kazutoshi Hayashi, Ozora Sasamoto, Riku Hirasawa, Toshinobu Korenaga,* Shintaro Ishida, Kanako Nozawa-Kumada, Yoshinori Kondo
J. Am. Chem. Soc., 2024, 146, 32452–32462. Link
☆Highlighted in SYNFACTS
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Synthesis of vinylidenecyclopropanes via gold(i)-catalyzed cyclopropanation
of vinyl arenes with γ-stannylated propargyl esters
Hiroto Mori, Yusuke Ono, Shota Nakagawa, Sota Akima, Miki Murakami, Toshinobu
Korenaga,* Tadashi Nakaji-Hirabayashi, Mayumi Kyogoku, Yoshikazu Horino*
Chem. Commun., 2024, Vol. 60, 13518-13521. Link
Selected as front cover.
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特許
反応性付与化合物
是永敏伸、村岡宏樹、桑静、吉田周平、中川瑞喜
特願2024-014431
2023
原著論文
LiHMDS-mediated deprotonative coupling of toluenes with ketones
Masanori Shigeno, Akihisa Kajima, Eito Toyama, Toshinobu Korenaga, Hiroyuki Yamakoshi, Kanako Nozawa-Kumada, Yoshinori Kondo
Chem. Eur. J., Vol. 29, e202203549, 2023. Link
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特許
ホスフィン化合物、配位子、金属錯体、及び、合成触媒
是永敏伸
特願2023-142889
2022
原著論文
Organic superbase t-Bu-P4-catalyzed demethylations of methoxyarene
Masanori Shigeno,* Kazutoshi Hayashi, Toshinobu Korenaga,* Kanako Nozawa-Kumada, Yoshinori Kondo*
Org. Chem. Front., Vol 9, pp. 3656-3663, 2022. Link
2021
原著論文
Versatile Reactivity of Metalloid-Substituted π-Allylpalladium Species
Yoshikazu Horino, Toshinobu Korenaga
Chem. Rec., Vol 21, pp. 3911-3924, 2021. Link
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Dynamic parallel kinetic resolution of α-ferrocenyl cation initiated by
chiral Brønsted acid catalyst
Yasunori Toda, Toshinobu Korenaga, Ren Obayashi, Jun Kikuchi, Masahiro
Terada
Chem. Sci., Vol 12, pp. 10306-10312, 2021. Link
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Palladium-Catalyzed Diastereoselective Synthesis of (Z)-Conjugated Enynyl Homoallylic Alcohols
Yoshikazu Horino, Mayo Ishibashi,Juri Sakamoto,Miki Murakami, Toshinobu
Korenaga
Adv. Synth. Catal., Vol 363, Issue 14, pp. 3592-3599, 2021. Link
2020
原著論文
Organic Solvent‐free Asymmetric 1,4‐Addition in Liquid‐ or Solid‐State using Conventional Stirring Catalyzed by a Chiral Rhodium Complex Developed as a Homogeneous Catalyst
Toshinobu Korenaga, Hiroto Kori, Shota Asai, Ryo Kowata, Masayuki Shirai
ChemCatChem, vol 12, pp. 6059-6066, 2020. Link
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Palladium-catalyzed reaction of γ-silylated allyl acetates proceeding through
1,2-shift of a substituent on silicon
Yoshikazu Horino, Mayo Ishibashi, Kosuke Nakasai, Toshinobu Korenaga
Tetarahedron, Vol 76, No.40, pp. 131493, 2020. Link
2019
原著論文
Enantioselective Acyl Migration Reactions of Furanyl Carbonates with Chiral DMAP Derivatives
Kazuki Fujii, Koichi Mitsudo, Hiroki Mandai, Toshinobu Korenaga, Seiji Suga
Chem. Eur. J., Vol. 25, pp. 2208-2212, 2019. Link
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総説・解説・著書
フッ素を有する高性能触媒の開発
是永敏伸
化学工業, Vol 70, No.8, pp21-30, 化学工業社, 2019.
2018
原著論文
Perfluorocyclopentadienyl Radical Derivative as an Organocatalyst for Oxidative Coupling of Aryl- and Thienylmagnesium Compounds under Atmospheric Oxygen
Toshinobu Korenaga, Kaoru Nitatori, Hiroki Muraoka, Satoshi Ogawa, Kazuaki Shimada
J. Org. Chem., Vol. 83, No. 8, pp. 4835-4839, 2018. Link
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A Short-step Conversion of Alkynyl Propargyl Sulfones into Six-membered
Cyclic β-Ketosulfones via an Amine-Induced Ring Closure
Md. Ashraful Alam, Kazuaki Shimada, Hironobu Kamoto, Kasumi Shingo, Toshinobu Korenaga, Chizuko Kabuto
Nat. Prod. Commun., Vol. 13, No. 5, pp. 593-598, 2018.
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Chiral Phosphoric Acid Catalyzed Enantioselective Ring Expansion Reaction of 1,3-Dithiane Derivatives: Case Study of the Nature of Ion-Pairing Interaction
Feng Li, Toshinobu Korenaga, Taishi Nakanishi, Jun Kikuchi, and Masahiro Terada
J. Am. Chem. Soc., Vol. 140, No. 7, pp. 2629-2642, 2018. Link
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A Short-step Synthesis of Onychine and the Related 4-Azafluorenones via Hetero Diels-Alder Reaction of 5-Substituted Isotellurazoles
Yusuke Taneichi, Kazuaki Shimada, Toshinobu Korenaga
Heterocycles, Vol. 96, No. 1, pp. 440-451, 2018.
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Moderately Flexible Trans-Chelating Diphosphine Ligands Consisting of Triazine Unit Showing High Ligand Acceleration Effect for Heck Reaction
Toshinobu Korenaga, Ryo Kowata ,Tomohiro Kotaki ,Yuji Shibasaki ,Yoshiyuki Oishi , Kazuaki Shimada
Bull. Chem. Soc. Jpn., Vol 91, No 4, pp. 577-584, 2018. Link
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Computationally-led Ligand Modification using Interplay between Theory and Experiments: Highly Active Chiral Rhodium Catalyst Controlled by Electronic Effects and CH–π Interactions
Toshinobu Korenaga, Ryo Sasaki, Toshihide Takemoto, Toshihisa Yasuda, Masahito Watanabe
Adv. Synth. Catal., Vol. 360, Issue 2, pp. 322-333, 2018 . Link
2017
原著論文
Total Synthesis and Structural Elucidation of Two Unusual Non-Methylene-Interrupted Fatty Acids in Ovaries of the Limpet Cellana toreuma
Kazuaki Shimada, Ayako Sugawara, Toshinobu, Korenaga, Hideki Kawashima
Lipids, Vol. 52, Issue 12, pp. 1019-1032, 2017. Link
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A Convenient Synthesis of Isotellurazoles via Deoxygenation of Isotellurazole
Te-Oxide Oligomers by Using a Combination of Ph3P/I2
Yusuke Taneichi, Kazuaki Shimada, Toshinobu, Korenaga
Heterocycles, Vol. 94, No. 10, pp. 1931-1939, 2017. Link
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Alkenecarbodithioate Esters from Substituted Propargyl Ethers, and Their Conversion into Isothiazole Ring through a [4+1] Type Oxidative Ring Closure
Kazuaki Shimada, Fumiya Ishikawa, Md. Ashraful Alam, Toshinobu, Korenaga
Nat. Prod. Commun., Vol. 12, No. 6, pp. 951-956, 2017.
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Rh-Catalyzed Dehydrogenative Cyclization Leading to Benzosilolothiophene Derivatives via Si–H/C–H Bond Cleavage
Koichi Mitsudo, Seiichi Tanaka, Ryota Isobuchi, Tomohiro Inada, Hiroki Manda, Toshinobu Korenaga, Atsushi Wakamiya, Yasujiro Murata, Seiji Suga
Org. Lett., Vol. 19, No. 10, pp. 2564-2567, 2017. Link
2016
原著論文
Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions
Hiroki Mandai, Kazuki Fujii, Hiroshi Yasuhara, Kenko Abe, Koichi Mitsudo, Toshinobu Korenaga, Seiji Suga
Nature Commun., Vol. 7, 11297, 2016. Link
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Synthesis of highly refractive and highly fluorescent rigid cyanuryl polyimines with polycyclic aromatic hydrocarbon pendants
T. Kotaki, N. Nishimura, M. Ozawa, A. Fujimori, H. Muraoka, S. Ogawa, T. Korenaga, E. Suzuki, Y. Oishi, and Y. Shibasaki
Polymer Chem., 7, pp. 1297-1308, 2016. Link
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Perfluorinated Aryls in the Design of Chiral Brønsted Acid Catalysts: Catalysis of Enantioselective [4 + 2] Cycloadditions and Ene Reactions of Imines with Alkenes by Chiral Mono-Phosphoric Acids with Perfluoroaryls
Norie Momiyama, Hiroshi Okamoto, Jun Kikuchi, Toshinobu Korenaga, Masahiro Terada
ACS Catal., Vol. 6, No. 2, pp. 1198–1204, 2016. Link
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EnantioselectiveAza Michael-Type Addition to AlkenylBenzimidazoles Catalyzed by aChiral PhosphoricAcid
Ya-YiWang, Kyohei Kanomata, Toshinobu Korenaga, Masahiro Terada
Angew. Chem. Int. Ed., Vol. 55, No. 3, pp. 927-931, 2016. Link
2015
原著論文
Development and Application of a Multielectron-Accepting Organic Oxidant for the Catalytic Transition-Metal-Free Oxidative Homocoupling of Grignard Reagents in Air
Toshinobu Korenaga, Kaoru Nitatori, Hiroki Muraoka, Satoshi Ogawa, Kazuaki Shimada
Org. Lett., Vol. 17, No. 21, pp. 5500–5503, 2015. Link
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Enantioselective Steglich Rearrangement of Oxindole Derivatives by Easily Accessible Chiral N,N-4-(Dimethylamino)pyridine Derivatives
Hiroki Mandai, Takuma Fujiwara, Katsuaki Noda, Kazuki Fujii, Koichi Mitsudo, Toshinobu Korenaga, Seiji Suga
Org. Lett., Vol. 17, No. 18, pp. 4436–4439, 2015. Link
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Highly Electron-poor Buchwald-type Ligand: Application for Pd-catalysed Direct Arylation of Thiophene Derivatives and Theoretical Consideration of the Secondary Pd0-arene Interaction
Toshinobu Korenaga, Ryo Sasaki, Kazuaki Shimada
Dalton Trans., Vol. 44, pp. 19642–19650, 2015. Link
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A Novel One-step synthesis of Quinoline-2(1H)-thiones and Selones by Treating 3-Aryl-3-(2-aminophenyl)-1-proryn-3-ols with a Base Elemental Sulfur or Selenium
Kazuaki Shimada, Hironori Izumi, Koki Otashiro, Kensuke Noro, Shigenobu Aoyagi, Yuji Takikawa, Toshinobu Korenaga
Nat. Prod. Commun., Vol. 10, No. 6, pp. 903-912, 2015.
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Ligand Effect on Direct Arylation by CMD Process
Toshinobu Korenaga, Noriki Suzuki, Masayoshi Sueda, Kazuaki Shimada
J. Organomet. Chem., Vol. 780, pp. 63-69, 2015. Link
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特許
含フッ素有機化合物及びこれとグリニャール試薬によるビアリール化合物の製造方法
是永敏伸, 似鳥馨
特願2015-119781
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総説・解説・著書
ペンタフルオロフェニルベンゼン
是永敏伸
フッ素化学入門2015, pp326-329, 三共出版 , 2015.
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[(S)-6,6'-ジメトキシ-1,1'-ビフェニル-2,2'-ジイル]- ビス[1,1-ビス(3,4,5-トリフルオロフェニル)ホスフィン]
是永敏伸
フッ素化学入門2015, pp348-351, 三共出版 , 2015.
2014
原著論文Mechanistic Studies of Highly Enantio- and Diastereoselective Aza-Petasis–Ferrier Rearrangement Catalyzed by Chiral Phosphoric Acid
Masahiro Terada, Takazumi Komuro, Yasunori Toda, Toshinobu Korenaga
J. Am. Chem. Soc., Vol. 136, No. 19, pp. 7044–7057, 2014. Link
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総説・解説・著書
FLP による水素分子活性化を利用した高性能不斉水素化触媒の開発
是永敏伸
有機分子触媒による未来型分子変換News Letter, No. 26, 2014.
2013
原著論文Low-Temperature Rh-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to α,β-Unsaturated Carbonyl Compounds
Toshinobu Korenaga, Aram Ko, Kazuaki Shimada
J. Org. Chem., Vol. 78, No. 19, pp. 9975–9980, 2013. Link
☆Most Read Articles ☆Highlighted in SYNFACTS
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The Shielding Effect of Fluoroaromatic Rings in NMR
Toshinobu Korenaga, Fuminao Kobayashi, Kenji Nomura, Takashi Sakai, Kazuaki Shimada
J. Fluorine Chem., Vol. 156, pp. 1-4, 2013. Link
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高度に電子不足な含フッ素アリールホスフィン配位子を用いた高効率的金属錯体触媒反応
是永敏伸
有機合成化学協会誌, Vol. 71, No. 1, pp.55-65, 2013.
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総説・解説・著書
電子不足な不斉ジホスフィン配位子を用いた触媒反応の高効率化
是永敏伸
触媒の設計･反応制御 事例集, 科学技術情報社, pp703-711, 2013.
2012
原著論文Biogenous Iron Oxide-immobilized Palladium Catalyst for the Solvent-free Suzuki-Miyaura Coupling Reaction
Kyoko Mandai, Toshinobu Korenaga, Tadashi Ema, Takashi Sakai, Mitsuaki Furutani, Hideki Hashimoto, Jun Takada
Tetrahedron Lett., Vol. 53, No. 3, pp. 329-332, 2012.
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総説・解説・著書
金属錯体触媒を超高活性化する新型リン配位子の開発
是永敏伸
化学工業, Vol. 63, No. 5, pp.329-336, 2012.
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遷移金属をルイス酸として用いるFrustrated Lewis Pairs
是永敏伸
Oraganometallic News, No. 2, pp.68, 2012.